Article
Structure-activity relationships in human interleukin-1 alpha: identification of key residues for expression of biological activities.
Protein engineering - 1 Mar 1992
Kawashima H, Yamagishi J, Yamayoshi M, Ohue M, Fukui T, Kotani H, Yamada M
Abstract excerpt
To identify the sites important for the different biological activities of human interleukin-1 alpha (hIL-1 alpha), 56 single-amino acid-substituted mutants of hIL-1 alpha were produced in Escherichia coli using site-directed mutagenesis, and were examined for their biological activities such as mouse lymphocyte activating factor activity (LAF activity), cytostatic activity against human melanoma cells A-375...
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