Article
The unglycosylated extracellular domain of type-II receptor for transforming growth factor-beta. A novel assay for characterizing ligand affinity and specificity.
European journal of biochemistry - 15 Oct 1996
Goetschy J F, Letourneur O, Cerletti N, Horisberger M A
Abstract excerpt
The activation of the human transforming growth factor (TGF-beta) system begins with the cytokine-induced association of the extracellular domains of two structurally related receptor subunits. To study the protein-protein interactions between TGF-beta and the ligand-specific receptor subunit, th...
Topics
- 3T3 Cells
- Animals
- Baculoviridae
- Base Sequence
- Binding, Competitive
- Cell Line
- Cloning, Molecular
- DNA, Complementary
- Glycosylation
- Humans
- In Vitro Techniques
- Ligands
- Mice
- Molecular Weight
- Mutation
- Protein Conformation
- Receptors, Transforming Growth Factor beta
- Recombinant Proteins