Characterization of mutated transforming growth factor-beta s which possess unique biological properties.

doi:10.1021/bi00206a037

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Article

Characterization of mutated transforming growth factor-beta s which possess unique biological properties.

Biochemistry - 11 Oct 1994

Qian S W, Burmester J K, Sun P D, Huang A, Ohlsen D J, Suardet L, Flanders K C, Davies D, Roberts A B, Sporn M B

Abstract excerpt

Transforming growth factor-beta (TGF-beta) is a potent regulator of cell growth and differentiation. On the basis of the crystal structure of TGF-beta 2, we have designed and synthesized two mutant TGF-beta s, TGF-beta 1 (71 Trp) and TGF-beta 1 (delta 69-73). Although both of these molecules inhi...

Topics

Amino Acid Sequence
Animals
Binding Sites
Blotting, Northern
CHO Cells
Carcinoembryonic Antigen
Cell Division
Cell Line
Colorectal Neoplasms
Cricetinae
Cross-Linking Reagents
Crystallography, X-Ray
Electrophoresis, Polyacrylamide Gel
Endothelium, Vascular
Feasibility Studies
Gene Expression Regulation, Neoplastic
Humans
Mink

Source

Open in PubMed

Identifiers

PMID: 7918451
DOI: 10.1021/bi00206a037

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7918451-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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