Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutational analysis of the C-terminus of human interferon-gamma.

Protein engineering - 1 Jul 1990

Wetzel R, Perry L J, Veilleux C, Chang G

Abstract excerpt

We have developed an expression/mutagenesis system and a series of screening procedures for the study of structure-function relationships in human interferon-gamma (HuIFN-gamma). Here we report a preliminary evaluation of the C-terminal portion of the molecule. An expression vector, p652trp gamma, was constructed which includes (i) the HuIFN-gamma gene under control of the trp promoter, (ii) elements controlling...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Mutation
Share to Molecular Sequence Data
Share to Amino Acid Sequence

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cloning, Molecular

Share to Electrophoresis, Polyacrylamide Gel

Share to Escherichia coli

Source

Identifiers

PMID: 2120696
DOI: 10.1093/protein/3.7.611

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutational analysis of the C-terminus of human interferon-gamma.PMID 2120696Read ↗

Mutational analysis of the C-terminus of human gamma-interferon.Semantic proximity Read ↗

Structure-function analysis of the human interferon gamma. The COOH terminus is not essential for functional activity.Semantic proximity Read ↗

Structure-function studies of interferon-alpha based on random mutagenesis and expression in vitro.Semantic proximity Read ↗

A point mutation of human interferon gamma abolishes receptor recognition.Semantic proximity Read ↗

Mutant human gamma-interferon with a truncated C-terminus and its properties.Semantic proximity Read ↗

A point mutation that decreases the thermal stability of human interferon gamma.Semantic proximity Read ↗

Carboxy-terminal truncated rhuIFN-gamma with a substitution of Gln133 or Ser132 to leucine leads to higher biological activity than in the wild type.Semantic proximity Read ↗

Systematic Mutational Mapping of Sites on Human Interferon-β-1a That Are Important for Receptor Binding and Functional ActivitySemantic proximity Read ↗

Evaluating the ability of different chaperones in improving soluble expression of a triple-mutated human interferon gamma in Escherichia coli.Semantic proximity Read ↗

[Mutant human gamma-interferons with varied C-termini and their properties].Semantic proximity Read ↗

[Mutant human gamma-interferons with a changed C-terminus and their properties].Semantic proximity Read ↗

Review of the recombinant human interferon gamma as an immunotherapeutic: Impacts of production platforms and glycosylationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.