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Article

A systematic mutational analysis of hormone-binding determinants in the human growth hormone receptor.

Proceedings of the National Academy of Sciences of the United States of America - 15 May 1991

Bass S H, Mulkerrin M G, Wells J A

Abstract excerpt

A mutational strategy is presented that allowed us to identify hormone-binding determinants in the extracellular portion of the human growth hormone receptor (hGHbp), a 238-residue protein with sequence homology to a number of cytokine receptors. By systematically replacing side chains with alanine we probed the importance of charged residues (49 total, typically located on the surface), aromatic residues (9...

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Identifiers

PMID: 2034689
DOI: 10.1073/pnas.88.10.4498
PMCID: PMC51688

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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