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Article

A systematic mutational analysis of hormone-binding determinants in the human growth hormone receptor.

Proceedings of the National Academy of Sciences of the United States of America - 15 May 1991

Bass S H, Mulkerrin M G, Wells J A

Abstract excerpt

A mutational strategy is presented that allowed us to identify hormone-binding determinants in the extracellular portion of the human growth hormone receptor (hGHbp), a 238-residue protein with sequence homology to a number of cytokine receptors. By systematically replacing side chains with alani...

Topics

Alanine
Amino Acid Sequence
Antibodies, Monoclonal
Binding Sites
Circular Dichroism
Cysteine
Fluorescence
Genetic Variation
Growth Hormone
Humans
Molecular Sequence Data
Mutagenesis, Site-Directed

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Receptors, Somatotropin

Tryptophan

Tyrosine

Source

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Identifiers

PMID: 2034689
DOI: 10.1073/pnas.88.10.4498
PMCID: PMC51688

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2034689-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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