Article
Refined histopathologic scoring system improves power to detect colitis QTL in mice.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Nov 2004
Bleich Andre, Mähler Michael, Most Claudia, Leiter Edward H, Liebler-Tenorio Elisabeth, Elson Charles O, Hedrich Hans J, Schlegelberger Brigitte, Sundberg John P
Abstract excerpt
Induction of colitis in mice by a targeted mutation in the I110 gene is inbred strain dependent. C3H/ HeJBir (C3H) mice are colitis susceptible while C57BL/6J (B6) mice are resistant. Identification of quantitative trait loci (QTL) determining the differential strain responsiveness requires histopathologic scoring of multiple lesion subphenotypes in both cecum and colon. Here we show that ability to detect a...
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