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Article

Computational immunohistochemical mapping adds immune context to histological phenotypes in mouse models of colitis.

Scientific reports - 1 Sept 2023

Kobayashi Soma, Sullivan Christopher, Bialkowska Agnieszka B, Saltz Joel H, Yang Vincent W

Abstract excerpt

Inflammatory bowel disease (IBD) is characterized by chronic, dysregulated inflammation in the gastrointestinal tract. The heterogeneity of IBD is reflected through two major subtypes, Crohn's Disease (CD) and Ulcerative Colitis (UC). CD and UC differ across symptomatic presentation, histology, immune responses, and treatment. While colitis mouse models have been influential in deciphering IBD pathogenesis, no...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37658187
DOI: 10.1038/s41598-023-41574-8
PMCID: PMC10474139

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