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Article

QTL analysis identifies a modifier locus of aganglionosis in the rat model of Hirschsprung disease carrying Ednrb(sl) mutations.

PloS one - 1 Jan 2011

Dang Ruihua, Torigoe Daisuke, Sasaki Nobuya, Agui Takashi

Abstract excerpt

Hirschsprung disease (HSCR) exhibits complex genetics with incomplete penetrance and variable severity thought to result as a consequence of multiple gene interactions that modulate the ability of enteric neural crest cells to populate the developing gut. As reported previously, when the same nul...

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Share to Chromosomes, Mammalian
Share to Crosses, Genetic
Share to Genes, Modifier

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Loci

Share to Hirschsprung Disease

Share to Organ Size

Share to Quantitative Trait, Heritable

Share to Receptor, Endothelin B

Source

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Identifiers

PMID: 22132166
DOI: 10.1371/journal.pone.0027902
PMCID: PMC3222640

Genes

EDNRB
GDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22132166-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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QTL analysis identifies a modifier locus of aganglionosis in the rat model of Hirschsprung disease carrying Ednrb(sl) mutations.PMID 22132166Read ↗

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