Genetic analysis of susceptibility to dextran sulfate sodium-induced colitis in mice.

doi:10.1006/geno.1998.5636

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Article

Genetic analysis of susceptibility to dextran sulfate sodium-induced colitis in mice.

Genomics - 15 Jan 1999

Mähler M, Bristol I J, Sundberg J P, Churchill G A, Birkenmeier E H, Elson C O, Leiter E H

Abstract excerpt

The genetic basis for differential sensitivity of inbred mice to inflammatory bowel disease induced by dextran sulfate sodium (DSS) is unknown. Susceptible C3H/HeJ were outcrossed to partially resistant C57BL/6J mice. F2 and N2 progeny were phenotyped by evaluating histopathologic lesions in larg...

Topics

Animals
Chromosome Mapping
Chromosomes
Colitis
Crosses, Genetic
Dextran Sulfate
Genetic Linkage
Genetic Markers
Genetic Predisposition to Disease
Genetic Variation
Mice
Mice, Inbred C3H
Mice, Inbred C57BL
Mice, Inbred NOD
Phenotype
Quantitative Trait, Heritable

Source

Open in PubMed

Identifiers

PMID: 9933561
DOI: 10.1006/geno.1998.5636

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9933561-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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