Mapping of chromosomal regions influencing immunological responses to gastrointestinal nematode infections in mice.

doi:10.1046/j.1365-3024.2003.00640.x

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Article

Mapping of chromosomal regions influencing immunological responses to gastrointestinal nematode infections in mice.

Parasite immunology - 1 Jun 2003

Menge David M, Behnke Jerzy M, Lowe Anna, Gibson John P, Iraqi Fuad A, Baker R Leyden, Wakelin Derek

Abstract excerpt

This paper reports the results of a genome-wide search for quantitative trait loci (QTL) influencing immunological responses to infection with the gastro-intestinal nematode parasite Heligmosomoides polygyrus in an F2 population created by crossing the resistant SWR and the susceptible CBA inbred mouse strains. Following infections, intestinal granuloma score at post mortem, mucosal mast cell protease 1, and IgE...

Topics

Animals
Antibodies, Helminth
Chromosome Mapping
Chymases
Crosses, Genetic
Feces
Female
Gastrointestinal Diseases
Genetic Predisposition to Disease
Genotype
Granuloma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Immunoglobulin E

Immunoglobulin G

Intestinal Mucosa

Male

Mice

Mice, Inbred CBA

Nematospiroides dubius

Source

Open in PubMed

Identifiers

PMID: 14507332
DOI: 10.1046/j.1365-3024.2003.00640.x

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