Article
TEF, an antiapoptotic bZIP transcription factor related to the oncogenic E2A-HLF chimera, inhibits cell growth by down-regulating expression of the common beta chain of cytokine receptors.
Blood - 1 Jun 2005
Inukai Takeshi, Inaba Toshiya, Dang Jinjun, Kuribara Ryoko, Ozawa Keiya, Miyajima Atsushi, Wu Wenshu, Look A Thomas, Arinobu Yojiro, Iwasaki Hiromi, Akashi Koichi, Kagami Keiko, Goi Kumiko, Sugita Kanji, Nakazawa Shinpei
Abstract excerpt
Gain and/or loss of function mediated by chimeric transcription factors generated by nonrandom translocations in leukemia is a key to understanding oncogenesis. E2A-hepatic leukemia factor (HLF), a chimeric basic region/leucine zipper (bZIP) transcription factor expressed in t(17;19)-positive leukemia cells, contributes to leukemogenesis through its potential to inhibit apoptosis. To identify physiologic...
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