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Article

Fusion of the Leucine Zipper Gene <i>HLF</i> to the <i>E2A</i> Gene in Human Acute B-Lineage Leukemia

24 Jul 1992

Abstract excerpt

A t(17;19) chromosomal translocation in early B-lineage acute leukemia was shown to result in chimeric transcripts that contain sequences from the E2A basic helix-loop-helix transcription factor gene on chromosome 19, fused to sequences from a previously unidentified gene (HLF) on chromosome 17 that encodes a hepatic leukemia factor. The chimeric protein consisted of the amino-terminal transactivation domain of...

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PMID: 1386162
DOI: 10.1126/science.1386162

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Related research

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Fusion of the Leucine Zipper Gene <i>HLF</i> to the <i>E2A</i> Gene in Human Acute B-Lineage LeukemiaPMID 1386162Read ↗

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