Cell transformation mediated by homodimeric E2A-HLF transcription factors.

doi:10.1128/MCB.17.3.1417

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Article

Cell transformation mediated by homodimeric E2A-HLF transcription factors.

Molecular and cellular biology - 1 Mar 1997

Inukai T, Inaba T, Yoshihara T, Look A T

Abstract excerpt

The E2A-HLF fusion gene, created by the t(17;19)(q22;p13) chromosomal translocation in pro-B lymphocytes, encodes an oncogenic protein in which the E2A trans-activation domain is linked to the DNA-binding and protein dimerization domain of hepatic leukemia factor (HLF), a member of the proline- a...

Topics

3T3 Cells
Animals
Basic-Leucine Zipper Transcription Factors
Cell Transformation, Neoplastic
DNA
DNA-Binding Proteins
Dimerization
Gene Expression Regulation, Neoplastic
Leucine Zippers
Mice
Mutation
Oncogene Proteins, Fusion
RNA, Messenger
Transcription Factors

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PMID: 9032268
DOI: 10.1128/MCB.17.3.1417
PMCID: PMC231866

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9032268-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.