Article
A somatic knockout of CBF1 in a human B-cell line reveals that induction of CD21 and CCR7 by EBNA-2 is strictly CBF1 dependent and that downregulation of immunoglobulin M is partially CBF1 independent.
Journal of virology - 1 Jul 2005
Maier Sabine, Santak Maja, Mantik Anja, Grabusic Kristina, Kremmer Elisabeth, Hammerschmidt Wolfgang, Kempkes Bettina
Abstract excerpt
CBF1 is a cellular highly conserved DNA binding factor that is ubiquitously expressed in all tissues and acts as a repressor of cellular genes. In Epstein-Barr virus growth-transformed B-cell lines, CBF1 serves as a central DNA adaptor molecule for several viral proteins, including the viral transactivator Epstein-Barr virus nuclear antigen 2 (EBNA-2). EBNA-2 binds to CBF1 and thereby gains access to regulatory...
Topics
- Alleles
- Burkitt Lymphoma
- Cell Line
- DNA-Binding Proteins
- Epstein-Barr Virus Nuclear Antigens
- Humans
- Immunoglobulin J Recombination Signal Sequence-Binding Protein
- Immunoglobulin M
- Nuclear Proteins
- Proto-Oncogene Proteins c-myc
- Receptors, CCR7
- Receptors, Chemokine