Negative regulation of granulocytic differentiation in the myeloid precursor cell line 32Dcl3 by ear -2, a mammalian homolog of Drosophila seven-up , and a chimeric leukemogenic gene, AML1/ETO ( MTG8 )

Abstract excerpt

The polyomavirus enhancer binding protein 2alphaB (AML1/PEBP2alphaB/Cbfa2) plays a pivotal role in granulocyte colony-stimulating factor (G-CSF)-mediated differentiation of a myeloid progenitor cell line, 32Dc13. In this article, we report the identification of a PEBP2alphaB interacting protein, Ear-2, an orphan member of the nuclear hormone receptor superfamily that directly binds to and can inhibit the function...

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