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em E2 em A basic helix-loop-helix transcription factors in human leukemia

1 Jan 2003

Abstract excerpt

The gene E2A on chromosome 19 is involved in recurrent chromosomal rearrangements associated with pediatric acute lymphoblastic leukemia. The resulting fusion of 5' E2A sequences with 3' portions of other genes leads to the expression of two well-characterized fusion proteins: E2A-PBX1 and E2A-HLF. Since the E2A, PBX1 and HLF proteins all appear to function as transcription factors, it appears likely that the...

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PMID: 12700034
DOI: 10.2741/1030

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