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Article

Identification of Zfp521/ZNF521 as a cooperative gene for E2A-HLF to develop acute B-lineage leukemia.

Oncogene - 1 Apr 2010

Yamasaki N, Miyazaki K, Nagamachi A, Koller R, Oda H, Miyazaki M, Sasaki T, Honda Z-i, Wolff L, Inaba T, Honda H

Abstract excerpt

E2A-hepatic leukemia factor (HLF) is a chimeric protein found in B-lineage acute lymphoblastic leukemia (ALL) with t(17;19). To analyze the leukemogenic process and to create model mice for t(17;19)-positive leukemia, we generated inducible knock-in (iKI) mice for E2A-HLF. Despite the induced exp...

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Source

Identifiers

PMID: 20062079
DOI: 10.1038/onc.2009.475

Genes

HLF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20062079-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Identification of Zfp521/ZNF521 as a cooperative gene for E2A-HLF to develop acute B-lineage leukemia.PMID 20062079Read ↗

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TEF, an antiapoptotic bZIP transcription factor related to the oncogenic E2A-HLF chimera, inhibits cell growth by down-regulating expression of the common beta chain of cytokine receptors.Semantic proximity Read ↗

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Zfp-51, a murine zinc finger encoding gene mapping to the t-complex region of chromosome 17, encodes 19 contiguous zinc fingers and is ubiquitously expressed.Semantic proximity Read ↗

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