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Article

Reversal of apoptosis by the leukaemia-associated E2A-HLF chimaeric transcription factor.

Nature - 8 Aug 1996

Inaba T, Inukai T, Yoshihara T, Seyschab H, Ashmun R A, Canman C E, Laken S J, Kastan M B, Look A T

Abstract excerpt

The E2A-HLF (for hepatic leukaemia factor) fusion gene, formed by action of the t(17;19) (q22;p13) chromosomal translocation, drives the leukaemic transformation of early B-cell precursors, but the mechanism of this activity remains unknown. Here we report that human leukaemia cells carrying the...

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Source

Identifiers

PMID: 8700228
DOI: 10.1038/382541a0

Genes

HLF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-8700228-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Reversal of apoptosis by the leukaemia-associated E2A-HLF chimaeric transcription factor.PMID 8700228Read ↗

TEF, an antiapoptotic bZIP transcription factor related to the oncogenic E2A-HLF chimera, inhibits cell growth by down-regulating expression of the common beta chain of cytokine receptors.Semantic proximity Read ↗

Cell transformation mediated by homodimeric E2A-HLF transcription factors.Semantic proximity Read ↗

Fusion of the Leucine Zipper Gene <i>HLF</i> to the <i>E2A</i> Gene in Human Acute B-Lineage LeukemiaSemantic proximity Read ↗

Up-regulation of survivin by the E2A-HLF chimera is indispensable for the survival of t(17;19)-positive leukemia cells.Semantic proximity Read ↗

Pivotal role for the NFIL3/E4BP4 transcription factor in interleukin 3-mediated survival of pro-B lymphocytesSemantic proximity Read ↗

Identification of Zfp521/ZNF521 as a cooperative gene for E2A-HLF to develop acute B-lineage leukemia.Semantic proximity Read ↗

Transformation of bone marrow B-cell progenitors by E2a-Hlf requires coexpression of Bcl-2.Semantic proximity Read ↗

em E2 em A basic helix-loop-helix transcription factors in human leukemiaSemantic proximity Read ↗

An African swine fever virus Bc1-2 homolog, 5-HL, suppresses apoptotic cell deathSemantic proximity Read ↗

Functional dissection of Bfl-1, a Bcl-2 homolog: anti-apoptosis, oncogene-cooperation and cell proliferation activities.Semantic proximity Read ↗

BCL2 translocation frequency rises with age in humans.Semantic proximity Read ↗

Apoptosis in a Fas-resistant, T-cell receptor-sensitive human leukaemic T-cell clone.Semantic proximity Read ↗

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