Article
Transformation of bone marrow B-cell progenitors by E2a-Hlf requires coexpression of Bcl-2.
Molecular and cellular biology - 1 Nov 2002
Smith Kevin S, Rhee Joon Whan, Cleary Michael L
Abstract excerpt
The chimeric transcription factor E2a-Hlf is an oncoprotein associated with a subset of acute lymphoblastic leukemias of early B-lineage derivation. We employed a retroviral transduction-transplantation approach to evaluate the oncogenic effects of E2a-Hlf on murine B-cell progenitors harvested from adult bone marrow. Expression of E2a-Hlf induced short-lived clusters of primary hematopoietic cells but no...
Topics
- Animals
- B-Lymphocytes
- Basic-Leucine Zipper Transcription Factors
- Blotting, Southern
- Blotting, Western
- Bone Marrow Cells
- Cell Division
- Cell Separation
- Cell Transformation, Neoplastic
- DNA
- DNA-Binding Proteins
- Disease Progression
- Flow Cytometry