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Article

Transformation of bone marrow B-cell progenitors by E2a-Hlf requires coexpression of Bcl-2.

Molecular and cellular biology - 1 Nov 2002

Smith Kevin S, Rhee Joon Whan, Cleary Michael L

Abstract excerpt

The chimeric transcription factor E2a-Hlf is an oncoprotein associated with a subset of acute lymphoblastic leukemias of early B-lineage derivation. We employed a retroviral transduction-transplantation approach to evaluate the oncogenic effects of E2a-Hlf on murine B-cell progenitors harvested from adult bone marrow. Expression of E2a-Hlf induced short-lived clusters of primary hematopoietic cells but no...

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Identifiers

PMID: 12370314
DOI: 10.1128/MCB.22.21.7678-7688.2002
PMCID: PMC135651

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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