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Article

Up-regulation of survivin by the E2A-HLF chimera is indispensable for the survival of t(17;19)-positive leukemia cells.

The Journal of biological chemistry - 15 Jan 2010

Okuya Mayuko, Kurosawa Hidemitsu, Kikuchi Jiro, Furukawa Yusuke, Matsui Hirotaka, Aki Daisuke, Matsunaga Takayuki, Inukai Takeshi, Goto Hiroaki, Altura Rachel A, Sugita Kenich, Arisaka Osamu, Look A Thomas, Inaba Toshiya

Abstract excerpt

The E2A-HLF fusion transcription factor generated by t(17;19)(q22;p13) translocation is found in a small subset of pro-B cell acute lymphoblastic leukemias (ALLs) and promotes leukemogenesis by substituting for the antiapoptotic function of cytokines. Here we show that t(17;19)+ ALL cells express Survivin at high levels and that a dominant negative mutant of E2A-HLF suppresses Survivin expression. Forced...

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Identifiers

PMID: 19887369
DOI: 10.1074/jbc.M109.023762
PMCID: PMC2804343

Genes

HLF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Up-regulation of survivin by the E2A-HLF chimera is indispensable for the survival of t(17;19)-positive leukemia cells.PMID 19887369Read ↗

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Aberrant induction of LMO2 by the E2A-HLF chimeric transcription factor and its implication in leukemogenesis of B-precursor ALL with t(17;19)Semantic proximity Read ↗

Identification of Zfp521/ZNF521 as a cooperative gene for E2A-HLF to develop acute B-lineage leukemia.Semantic proximity Read ↗

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