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Article

A constitutively active GPCR retains its G protein specificity and the ability to form dimers.

Molecular microbiology - 1 Jan 2005

Ladds Graham, Davis Kevin, Das Anamika, Davey John

Abstract excerpt

G protein-coupled receptors (GPCRs) are cell surface proteins which help to regulate the physiology of all the major organ systems within higher eukaryotes. They are stimulated by multiple ligands and activate a range of effector molecules to bring about changes in cell behaviour. The use of constitutively active mutants (CAMs) of GPCRs has enabled a better understanding of receptor activation as CAMs exhibit...

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Identifiers

PMID: 15659165
DOI: 10.1111/j.1365-2958.2004.04394.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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