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Article

Spontaneous receptor-independent heterotrimeric G-protein signalling in an RGS mutant.

Nature cell biology - 1 Mar 2003

Siekhaus Daria E, Drubin David G

Abstract excerpt

Tripartite G-protein-coupled receptors (GPCRs) represent one of the largest groups of signal transducers, transmitting signals from hormones, neuropeptides, odorants, food and light. Ligand-bound receptors catalyse GDP/GTP exchange on the G-protein alpha-subunit (Galpha), leading to alpha-GTP separation from the betagamma subunits and pathway activation. Activating mutations in the receptors or G proteins...

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Identifiers

PMID: 12598904
DOI: 10.1038/ncb941

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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