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Article

Mechanisms governing the activation and trafficking of yeast G protein-coupled receptors.

Molecular biology of the cell - 1 Apr 1998

Stefan C J, Overton M C, Blumer K J

Abstract excerpt

We have addressed the mechanisms governing the activation and trafficking of G protein-coupled receptors (GPCRs) by analyzing constitutively active mating pheromone receptors (Ste2p and Ste3p) of the yeast Saccharomyces cerevisiae. Substitution of the highly conserved proline residue in transmembrane segment VI of these receptors causes constitutive signaling. This proline residue may facilitate folding of GPCRs...

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Identifiers

PMID: 9529386
DOI: 10.1091/mbc.9.4.885
PMCID: PMC25315

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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