Article
Genome-wide analyses identify NEAT1 as genetic modifier of age at onset of amyotrophic lateral sclerosis.
Molecular neurodegeneration - 23 Oct 2023
Li Chunyu, Wei Qianqian, Hou Yanbing, Lin Junyu, Ou Ruwei, Zhang Lingyu, Jiang Qirui, Xiao Yi, Liu Kuncheng, Chen Xueping, Yang TianMi, Song Wei, Zhao Bi, Wu Ying, Shang Huifang
Abstract excerpt
BACKGROUND: Patients with amyotrophic lateral sclerosis (ALS) demonstrate great heterogeneity in the age at onset (AAO), which is closely related to the course of disease. However, most genetic studies focused on the risk of ALS, while the genetic background underlying AAO of ALS is still unknown. METHODS: To identify genetic determinants influencing AAO of ALS, we performed genome-wide association analysis using...
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