Article
Age of onset of amyotrophic lateral sclerosis is modulated by a locus on 1p34.1.
Neurobiology of aging - 1 Jan 2013
Ahmeti Kreshnik B, Ajroud-Driss Senda, Al-Chalabi Ammar, Andersen Peter M, Armstrong Jennifer, Birve Anne, Blauw Hylke M, Brown Robert H, Bruijn Lucie, Chen Wenjie, Chio Adriano, Comeau Mary C, Cronin Simon, Diekstra Frank P, Soraya Gkazi Athina, Glass Jonathan D, Grab Josh D, Groen Ewout J, Haines Jonathan L, Hardiman Orla, Heller Scott, Huang Jie, Hung Wu-Yen, Jaworski James M, Jones Ashley, Khan Humaira, Landers John E, Langefeld Carl D, Leigh P Nigel, Marion Miranda C, McLaughlin Russell L, Meininger Vincent, Melki Judith, Miller Jack W, Mora Gabriele, Pericak-Vance Margaret A, Rampersaud Evadnie, Robberecht Wim, Russell Laurie P, Salachas Francois, Saris Christiaan G, Shatunov Aleksey, Shaw Christopher E, Siddique Nailah, Siddique Teepu, Smith Bradley N, Sufit Robert, Topp Simon, Traynor Bryan J, Vance Caroline, van Damme Philip, van den Berg Leonard H, van Es Michael A, van Vught Paul W, Veldink Jan H, Yang Yi, Zheng J G
Abstract excerpt
Amyotrophic lateral sclerosis (ALS) is the third most common adult-onset neurodegenerative disease. Individuals with ALS rapidly progress to paralysis and die from respiratory failure within 3 to 5 years after symptom onset. Epidemiological factors explain only a modest amount of the risk for ALS. However, there is growing evidence of a strong genetic component to both familial and sporadic ALS risk. The...
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