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Genetic Modifiers of Age at Onset for Amyotrophic Lateral Sclerosis: A Genome-Wide Association Study.

Annals of neurology - 1 Nov 2023

Li Chunyu, Lin Junyu, Jiang Qirui, Yang Tianmi, Xiao Yi, Huang Jingxuan, Hou Yanbing, Wei Qianqian, Cui Yiyuan, Wang Shichan, Zheng Xiaoting, Ou Ruwei, Liu Kuncheng, Chen Xueping, Song Wei, Zhao Bi, Shang Huifang

Abstract excerpt

OBJECTIVE: Age at onset (AAO) is an essential clinical feature associated with disease progression and mortality in amyotrophic lateral sclerosis (ALS). Identification of genetic variants and environmental risk factors influencing AAO of ALS could help better understand the disease's biological mechanism and provide clinical guidance. However, most genetic studies focused on the risk of ALS, while the genetic...

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PMID: 37528491
DOI: 10.1002/ana.26752

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