Article
Apolipoprotein E controls the risk and age at onset of Parkinson disease.
Neurology - 8 Jun 2004
Li Y J, Hauser M A, Scott W K, Martin E R, Booze M W, Qin X J, Walter J W, Nance M A, Hubble J P, Koller W C, Pahwa R, Stern M B, Hiner B C, Jankovic J, Goetz C G, Small G W, Mastaglia F, Haines J L, Pericak-Vance M A, Vance J M
Abstract excerpt
BACKGROUND: Similarities between Alzheimer disease (AD) and Parkinson disease (PD) suggest a possible role for apolipoprotein E (APOE) in PD. Most previous studies seeking to establish such a link used case-control datasets and results have been inconsistent. OBJECTIVE: To investigate APOE's role in PD using family-based association analyses. METHODS: APOE functional polymorphisms were genotyped for 658 PD...
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