Article

TRF2 promotes dynamic and stepwise looping of POT1 bound telomeric overhang

2020-09-22

Abstract excerpt

<title>Abstract</title> <p>Human telomeres are protected by shelterin components including POT1 and TRF2 but the molecular mechanism remains elusive. Here, we report an unexpected activity of POT1 in imparting conformational dynamics of the telomere overhang, even at a monomer level. Such POT1 induced overhang dynamics is greatly enhanced when TRF2 engages with the telomere duplex. Strikingly, TRF2 brings a POT1...

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Identifiers and source

Literature Corpus work: d302dc4a-c970-5ec3-a7a7-f8007115751c
DOI: 10.21203/rs.3.rs-79038/v1

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