Article
CYP1A1 alleles in female genital cancers in the Polish population.
European journal of obstetrics, gynecology, and reproductive biology - 1 Feb 2005
Seremak-Mrozikiewicz Agnieszka, Drews Krzysztof, Semczuk Andrzej, Jakowicki Jerzy A, Mrozikiewicz Przemyslaw M
Abstract excerpt
OBJECTIVE: Cytochrome P4501A1 (CYP1A1) plays an important role in the bioactivation processes that transform aromatic hydrocarbons into ultimate carcinogens. Genetically determined differences in activity of this enzyme could modulate individual susceptibility to develop cancers. The role of CYP1A1 in metabolic pathway of estrogens suggests an influence on carcinogenic events in genital tissues. The aim of our...
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