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Article

CYP1A1 polymorphism and risk of gynecological malignancy in Japan.

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society - 1 Jan 2000

Sugawara T, Nomura E, Sagawa T, Sakuragi N, Fujimoto S

Abstract excerpt

The incidence of endometrial cancer and ovarian cancer in Japan has been increasing in recent years. Results of epidemiologic studies suggest that the onset and multiplication of these cancers are associated with estrogen. Estrogens are metabolized by cytochrome P450 1A1 (CYP1A1) and converted into catecholestrogens, which are carcinogens. CYP1A1 has several polymorphisms, the major one being T6235C transition in...

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PMID: 14675315
DOI: 10.1111/j.1525-1438.2003.13607.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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