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Article

TNFα-stimulated gene-6 (TSG6) activates macrophage phenotype transition to prevent inflammatory lung injury.

Proceedings of the National Academy of Sciences of the United States of America - 13 Dec 2016

Mittal Manish, Tiruppathi Chinnaswamy, Nepal Saroj, Zhao You-Yang, Grzych Dagmara, Soni Dheeraj, Prockop Darwin J, Malik Asrar B

Abstract excerpt

TNFα-stimulated gene-6 (TSG6), a 30-kDa protein generated by activated macrophages, modulates inflammation; however, its mechanism of action and role in the activation of macrophages are not fully understood. Here we observed markedly augmented LPS-induced inflammatory lung injury and mortality in TSG6-/- mice compared with WT (TSG6+/+) mice. Treatment of mice with intratracheal instillation of TSG6 prevented...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27911817
DOI: 10.1073/pnas.1614935113
PMCID: PMC5167170

Genes

STAT1
STAT3
TLR4
CXCL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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