Article
The resistance of P. acnes--primed interferon gamma-deficient mice to low-dose lipopolysaccharide-induced acute liver injury.
Hepatology (Baltimore, Md.) - 1 Apr 2002
Shimizu Yoshiaki, Margenthaler Julie A, Landeros Keith, Otomo Naoki, Doherty Gerard, Flye M Wayne
Abstract excerpt
Endotoxin has been identified as a principal mediator of sepsis, often with resulting multiple organ failure. Although interferon gamma (IFN-gamma) has a central role in controlling bacterial infection through the activation of macrophages and T lymphocytes, it can also enhance the harmful effects of the inflammatory response. To examine the role of IFN-gamma in lipopolysaccharide (LPS)-induced injury, we...
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