Article

IL-6 knockout alleviates inflammatory response and improve acute lung injury via regulating macrophage polarization in sepsis

2021-10-01

Abstract excerpt

<h4>Background: </h4> Sepsis is a fatal disease with a high rate of morbidity and mortality, during which acute lung injury is the earliest and most serious complication. Macrophage plays a crucial role in the initiation and progress of sepsis. This study meant to explore the effect of IL-6 knockout in CLP induced sepsis.MethodsIn this study, cecal ligation and puncture (CLP) was performed on wildtype and interleu...

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Literature Corpus work: 01322d8f-870a-5777-9e3d-c14ea4f5a1d0
DOI: 10.21203/rs.3.rs-618570/v2

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