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Article

Absence of endogenous interleukin-6 enhances the inflammatory response during acute pancreatitis induced by cerulein in mice.

Cytokine - 7 Jun 2002

Cuzzocrea Salvatore, Mazzon Emanuela, Dugo Laura, Centorrino Tommaso, Ciccolo Antonio, McDonald Michelle C, de Sarro Agelina, Caputi Achille P, Thiemermann Christoph

Abstract excerpt

Interleukin-6 (IL-6) exerts a wide spectrum of regulatory activities during immune and inflammatory responses. The aim of this study was to investigate the role of endogenous IL-6 in the inflammatory response associated with acute pancreatitis. Acute pancreatitis was induced by hourly (x5) i.p. injections of cerulein (50 microg/kg, suspended in saline solution) in IL-6 deficient mice (IL-6-KO) and wild-type...

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Identifiers

PMID: 12161103
DOI: 10.1006/cyto.2002.0883

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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