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Article

Artesunate strongly modulates myeloid and regulatory T cells to prevent LPS-induced systemic inflammation.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - 1 Nov 2021

Mancuso Rubia Isler, Azambuja Juliana Hofstätter, Olalla Saad Sara Teresinha

Abstract excerpt

Lipopolysaccharide (LPS) is the major component of the outer membrane of Gram-negative bacteria and is usually administrated to establish models of inflammation. Artesunate (ART), a water-soluble artemisinin derivative, displays multiple pharmacological actions against tumors, viral infections, and inflammation, and has been used as a therapeutic weapon against malaria. In this study, our aim was to evaluate...

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Identifiers

PMID: 34649344
DOI: 10.1016/j.biopha.2021.112211

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