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Article

IL-6 Mutation Attenuates Liver Injury Caused by Aeromonas hydrophila Infection by Reducing Oxidative Stress in Zebrafish.

International journal of molecular sciences - 7 Dec 2023

Zhai Wenya, Wang Zhensheng, Ye Canxun, Ke Lan, Wang Huanling, Liu Hong

Abstract excerpt

Interleukin-6 (IL-6), a pleiotropic cytokine, plays a crucial role in acute stress induced by bacterial infection and is strongly associated with reactive oxygen species (ROS) production. However, the role of IL-6 in the liver of fish after Aeromonas hydrophila infection remains unclear. Therefore, this study constructed a zebrafish (Danio rerio) il-6 knockout line by CRISPR/Cas9 to investigate the function of...

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Identifiers

PMID: 38139043
DOI: 10.3390/ijms242417215
PMCID: PMC10743878

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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