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Inhibition of SIRT6 aggravates p53-mediated ferroptosis in acute lung injury in mice

1 Nov 2023

Abstract excerpt

Although studies have shown that protein 53 (p53)-mediated ferroptosis is involved in acute lung injury (ALI), the mechanism of its regulation remains unclear. The protective effects of Sirtuin 6 (SIRT6), a histone deacetylase, have been demonstrated in multiple diseases; however, further studies are needed to elucidate the role of SIRT6 in ALI. In the present study, we hypothesize that SIRT6 protects against...

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PMID: 38034611
DOI: 10.1016/j.heliyon.2023.e22272

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