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Article

Deletion of the mouse T-cell receptor beta gene enhancer blocks alphabeta T-cell development.

Proceedings of the National Academy of Sciences of the United States of America - 23 Jul 1996

Bouvier G, Watrin F, Naspetti M, Verthuy C, Naquet P, Ferrier P

Abstract excerpt

Intrathymic T-cell development requires temporally regulated rearrangement and expression of T-cell receptor (TCR) genes. To assess the role of the TCR beta gene transcriptional enhancer (Ebeta) in this process, mouse strains in which Ebeta is deleted were generated using homologous recombination techniques. We report that mice homozygous for the Ebeta deletion, whether a selectable marker gene is present or not,...

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Identifiers

PMID: 8755570
DOI: 10.1073/pnas.93.15.7877
PMCID: PMC38842

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Deletion of the mouse T-cell receptor beta gene enhancer blocks alphabeta T-cell development.PMID 8755570Read ↗

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Mutations in T-cell antigen receptor genes alpha and beta block thymocyte development at different stages.Semantic proximity Read ↗

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Allelic exclusion in pTalpha-deficient mice: no evidence for cell surface expression of two T cell receptor (TCR)-beta chains, but less efficient inhibition of endogeneous Vbeta--> (D)Jbeta rearrangements in the presence of a functional TCR-beta transgene.Semantic proximity Read ↗

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