Article
T cell receptor (TCR) alpha/delta locus enhancer identity and position are critical for the assembly of TCR delta and alpha variable region genes.
Proceedings of the National Academy of Sciences of the United States of America - 4 Mar 2003
Bassing Craig H, Tillman Robert E, Woodman Barbara B, Canty David, Monroe Robert J, Sleckman Barry P, Alt Frederick W
Abstract excerpt
T cell receptor (TCR) delta and alpha variable region genes are assembled from germ-line gene segments located in a single chromosomal locus in which TCR delta segments are situated between TCR alpha segments. The TCR alpha enhancer (E alpha) located at the 3' end of the TCR alpha/delta locus functions over a long chromosomal distance to promote TCR alpha rearrangement and maximal TCR delta expression; whereas...
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