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Article

Ect2 and MgcRacGAP regulate the activation and function of Cdc42 in mitosis.

The Journal of cell biology - 17 Jan 2005

Oceguera-Yanez Fabian, Kimura Kazuhiro, Yasuda Shingo, Higashida Chiharu, Kitamura Toshio, Hiraoka Yasushi, Haraguchi Tokuko, Narumiya Shuh

Abstract excerpt

Although Rho regulates cytokinesis, little was known about the functions in mitosis of Cdc42 and Rac. We recently suggested that Cdc42 works in metaphase by regulating bi-orient attachment of spindle microtubules to kinetochores. We now confirm the role of Cdc42 by RNA interference and identify the mechanisms for activation and down-regulation of Cdc42. Using a pull-down assay, we found that the level of...

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Identifiers

PMID: 15642749
DOI: 10.1083/jcb.200408085
PMCID: PMC2171585

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Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Ect2 and MgcRacGAP regulate the activation and function of Cdc42 in mitosis.PMID 15642749Read ↗

Cdc42 and mDia3 regulate microtubule attachment to kinetochores.Semantic proximity Read ↗

Asymmetric positioning and organization of the meiotic spindle of mouse oocytes requires CDC42 function.Semantic proximity Read ↗

Inhibition of cyclin-dependent kinase 1 induces cytokinesis without chromosome segregation in an ECT2 and MgcRacGAP-dependent manner.Semantic proximity Read ↗

MgcRacGAP is involved in cytokinesis through associating with mitotic spindle and midbody.Semantic proximity Read ↗

Cdc42 GTPase regulates ESCRTs in nuclear envelope sealing and ER remodeling.Semantic proximity Read ↗

Crm1 is a mitotic effector of Ran-GTP in somatic cells.Semantic proximity Read ↗

Plasma Membrane Association but Not Midzone Recruitment of RhoGEF ECT2 Is Essential for Cytokinesis.Semantic proximity Read ↗

An ECT2-centralspindlin complex regulates the localization and function of RhoA.Semantic proximity Read ↗

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The gamma-subunit of the coatomer complex binds Cdc42 to mediate transformation.Semantic proximity Read ↗

The tandem BRCT domains of Ect2 are required for both negative and positive regulation of Ect2 in cytokinesis.Semantic proximity Read ↗

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