Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The tandem BRCT domains of Ect2 are required for both negative and positive regulation of Ect2 in cytokinesis.

The Journal of biological chemistry - 18 Feb 2005

Kim Ja-Eun, Billadeau Daniel D, Chen Junjie

Abstract excerpt

Epithelial cell transforming protein 2 (Ect2) is a guanine nucleotide exchange factor (GEF) for Rho GTPases, molecular switches essential for the control of cytokinesis in mammalian cells. Aside from the canonical Dbl homology/pleckstrin homology cassette found in virtually all Dbl family members...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Catalysis
Share to Catalytic Domain
Share to Cytokinesis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HeLa Cells

Share to Protein Structure, Tertiary

Share to Proto-Oncogene Proteins

Share to rhoA GTP-Binding Protein

Share to RNA, Small Interfering

Source

Identifiers

PMID: 15545273
DOI: 10.1074/jbc.M409298200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15545273-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The tandem BRCT domains of Ect2 are required for both negative and positive regulation of Ect2 in cytokinesis.PMID 15545273Read ↗

The Ect2 Rho Guanine Nucleotide Exchange Factor Is Essential for Early Mouse Development and Normal Cell Cytokinesis and MigrationSemantic proximity Read ↗

Deregulation and mislocalization of the cytokinesis regulator ECT2 activate the Rho signaling pathways leading to malignant transformation.Semantic proximity Read ↗

The Sec14 homology domain regulates the cellular distribution and transforming activity of the Rho-specific guanine nucleotide exchange factor Dbs.Semantic proximity Read ↗

Leukemia-associated RhoGEF (LARG) is a novel RhoGEF in cytokinesis and required for the proper completion of abscission.Semantic proximity Read ↗

Augmenting E Protein Activity Impairs cDC2 Differentiation at the Pre-cDC Stage.Semantic proximity Read ↗

Structure and regulation of human epithelial cell transforming 2 protein.Semantic proximity Read ↗

Double bromodomain-containing gene Brd2 is essential for embryonic development in mouse.Semantic proximity Read ↗

Identification and characterization of hPEM-2, a guanine nucleotide exchange factor specific for Cdc42.Semantic proximity Read ↗

Two bromodomain proteins functionally interact to recapitulate an essential BRDT-like function in Drosophila spermatocytes.Semantic proximity Read ↗

The Conserved 12-Amino Acid Stretch in the Inter-Bromodomain Region of BET Family Proteins Functions as a Nuclear Localization SignalSemantic proximity Read ↗

DRhoGEF2 regulates actin organization and contractility in the Drosophila blastoderm embryo.Semantic proximity Read ↗

Ect2 and MgcRacGAP regulate the activation and function of Cdc42 in mitosis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.