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Article

Inhibition of cyclin-dependent kinase 1 induces cytokinesis without chromosome segregation in an ECT2 and MgcRacGAP-dependent manner.

The Journal of biological chemistry - 28 Oct 2005

Niiya Fumihiko, Xie Xiaozhen, Lee Kyung S, Inoue Hiroki, Miki Toru

Abstract excerpt

Cleavage furrow formation marks the onset of cell division during early anaphase. The small GTPase RhoA and its regulators ECT2 and MgcRacGAP have been implicated in furrow ingression in mammalian cells, but the signaling upstream of these molecules remains unclear. We now show that the inhibition of cyclin-dependent kinase (Cdk)1 is sufficient to initiate cytokinesis. When mitotically synchronized cells were...

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Source

Identifiers

PMID: 16118207
DOI: 10.1074/jbc.M508007200

Genes

ECT2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Inhibition of cyclin-dependent kinase 1 induces cytokinesis without chromosome segregation in an ECT2 and MgcRacGAP-dependent manner.PMID 16118207Read ↗

The degradation of two mitotic cyclins contributes to the timing of cytokinesis.Semantic proximity Read ↗

Parallel chemical genetic and genome-wide RNAi screens identify cytokinesis inhibitors and targets.Semantic proximity Read ↗

MgcRacGAP regulates cortical activity through RhoA during cytokinesis.Semantic proximity Read ↗

Exit from mitosis is regulated by Drosophila fizzy and the sequential destruction of cyclins A, B and B3.Semantic proximity Read ↗

The NoCut pathway links completion of cytokinesis to spindle midzone function to prevent chromosome breakage.Semantic proximity Read ↗

Mechanisms for concentrating Rho1 during cytokinesis.Semantic proximity Read ↗

PRC1 is a microtubule binding and bundling protein essential to maintain the mitotic spindle midzone.Semantic proximity Read ↗

Fine tuning the cell cycle: activation of the Cdk1 inhibitory phosphorylation pathway during mitotic exit.Semantic proximity Read ↗

Commitment to cytokinetic furrowing requires the coordinate activity of microtubules and Plk1Semantic proximity Read ↗

p190RhoGAP is cell cycle regulated and affects cytokinesis.Semantic proximity Read ↗

Ect2 and MgcRacGAP regulate the activation and function of Cdc42 in mitosis.Semantic proximity Read ↗

Anillin is a substrate of anaphase-promoting complex/cyclosome (APC/C) that controls spatial contractility of myosin during late cytokinesis.Semantic proximity Read ↗

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