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Article

An ECT2-centralspindlin complex regulates the localization and function of RhoA.

The Journal of cell biology - 15 Aug 2005

Yüce Ozlem, Piekny Alisa, Glotzer Michael

Abstract excerpt

In anaphase, the spindle dictates the site of contractile ring assembly. Assembly and ingression of the contractile ring involves activation of myosin-II and actin polymerization, which are triggered by the GTPase RhoA. In many cells, the central spindle affects division plane positioning via unknown molecular mechanisms. Here, we dissect furrow formation in human cells and show that the RhoGEF ECT2 is required...

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Source

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Identifiers

PMID: 16103226
DOI: 10.1083/jcb.200501097
PMCID: PMC2171506

Genes

ECT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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An ECT2-centralspindlin complex regulates the localization and function of RhoA.PMID 16103226Read ↗

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