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Article

Plasma Membrane Association but Not Midzone Recruitment of RhoGEF ECT2 Is Essential for Cytokinesis.

Cell reports - 6 Dec 2016

Kotýnková Kristýna, Su Kuan-Chung, West Stephen C, Petronczki Mark

Abstract excerpt

Cytokinesis, the final step of cell division, begins with the formation of a cleavage furrow. How the mitotic spindle specifies the furrow at the equator in animal cells remains unknown. Current models propose that the concentration of the RhoGEF ECT2 at the spindle midzone and the equatorial plasma membrane directs furrow formation. Using chemical genetic and optogenetic tools, we demonstrate that the...

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Identifiers

PMID: 27926870
DOI: 10.1016/j.celrep.2016.11.029
PMCID: PMC5177604

Genes

ECT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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