Article
Variation at the paraoxonase gene locus contributes to carotid arterial wall thickness in subjects with familial hypercholesterolemia.
Clinical biochemistry - 1 Feb 2005
Roest Mark, Jansen Angelique C M, Barendrecht Arjan, Leus Frank R, Kastelein John J P, Voorbij Hieronymus A M
Abstract excerpt
OBJECTIVES: Paraoxonase (PON1) is a potent enzyme, physically associated with the high-density lipoprotein particle. PON1 may protect against cardiovascular disease (CVD), since it is capable of hydrolyzing oxidized LDL-cholesterol, thereby negating the detrimental effects of this lipoprotein on the arterial wall. DESIGN AND METHODS: In 187 patients with familial hypercholesterolemia, we studied the seven most...
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