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Article

TagSNP analyses of the PON gene cluster: effects on PON1 activity, LDL oxidative susceptibility, and vascular disease.

Journal of lipid research - 1 May 2006

Carlson Christopher S, Heagerty Patrick J, Hatsukami Thomas S, Richter Rebecca J, Ranchalis Jane, Lewis Julieann, Bacus Tamara J, McKinstry Laura A, Schellenberg Gerard D, Rieder Mark, Nickerson Deborah, Furlong Clement E, Chait Alan, Jarvik Gail P

Abstract excerpt

Paraoxonase 1 (PON1) activity is consistently predictive of vascular disease, although the genotype at four functional PON1 polymorphisms is not. To address this inconsistency, we investigated the role of all common PON1 genetic variability, as measured by tagging single-nucleotide polymorphisms (tagSNPs), in predicting PON1 activity for phenylacetate hydrolysis, LDL susceptibility to oxidation ex vivo, plasma...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16474172
DOI: 10.1194/jlr.M500517-JLR200

Genes

PON1
PON2
PON3

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TagSNP analyses of the PON gene cluster: effects on PON1 activity, LDL oxidative susceptibility, and vascular disease.PMID 16474172Read ↗

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