Article
The correlation of paraoxonase (PON1) activity with lipid and lipoprotein levels differs with vascular disease status.
Journal of lipid research - 1 Sept 2005
Rozek Laura S, Hatsukami Thomas S, Richter Rebecca J, Ranchalis Jane, Nakayama Karen, McKinstry Laura A, Gortner David A, Boyko Edward, Schellenberg Gerard D, Furlong Clement E, Jarvik Gail P
Abstract excerpt
Paraoxonase (PON1) is an HDL-associated enzyme. Low PON1 activity predicts vascular disease status and is a more reliable predictor of vascular disease than are functional PON1 genotypes. There is evidence that the relationship of PON1 to vascular disease is, in part, due to its antioxidant activity. However, the physical relationship of PON1 with HDL and the existence of cholesterol pathway regulatory elements...
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