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Article

Influence of the human paraoxonase polymorphism (PON1 192) on the carotid-wall thickening in a healthy population.

Coronary artery disease - 1 Dec 1999

Dessì M, Gnasso A, Motti C, Pujia A, Irace C, Casciani S, Staffa F, Federici G, Cortese C

Abstract excerpt

BACKGROUND: Serum paraoxonase (PON1) is a high-density lipoprotein-bound enzyme that can prevent oxidation of low-density lipoprotein and thus exert an anti-atherogenic effect. A polymorphism at codon 192 (Gln/Arg) of the PON1 gene gives rise to two isoforms that differ in substrate-dependent activity. OBJECTIVE: To determine any independent contribution of this polymorphism to the variability of intimal-medial...

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Source

Identifiers

PMID: 10599538
DOI: 10.1097/00019501-199912000-00008

Genes

PON1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Influence of the human paraoxonase polymorphism (PON1 192) on the carotid-wall thickening in a healthy population.PMID 10599538Read ↗

p.Q192R SNP of PON1 seems not to be Associated with Carotid Atherosclerosis Risk Factors in an Asymptomatic and Normolipidemic Brazilian Population Sample.Semantic proximity Read ↗

The Arg allele in position 192 of PON1 is associated with carotid atherosclerosis in subjects with elevated HDLs.Semantic proximity Read ↗

Variation at the paraoxonase gene locus contributes to carotid arterial wall thickness in subjects with familial hypercholesterolemia.Semantic proximity Read ↗

Paraoxonase gene polymorphisms are associated with carotid arterial wall thickness in subjects with familial hypercholesterolemia.Semantic proximity Read ↗

The paraoxonase-1 codon 192 polymorphism is associated with fasting total cholesterol and LDL-cholesterol concentrations only in postmenopausal women. The REGICOR study.Semantic proximity Read ↗

Paraoxonase1-192 polymorphism modulates the nonfatal myocardial infarction risk associated with decreased HDLs.Semantic proximity Read ↗

Genetic and environmental determinants of the PON-1 phenotype.Semantic proximity Read ↗

Paraoxonase (PON)-1: a brief overview on genetics, structure, polymorphisms and clinical relevance.Semantic proximity Read ↗

The 192R/Q polymorphs of serum paraoxonase PON1 differ in HDL binding, lipolactonase stimulation, and cholesterol efflux.Semantic proximity Read ↗

Paraoxonase 192 Gln-->Arg polymorphism: an independent risk factor for nonfatal arterial ischemic stroke among young adults.Semantic proximity Read ↗

Paraoxonase activity in two healthy populations with differing rates of coronary heart disease.Semantic proximity Read ↗

Genetic polymorphisms of paraoxonase 1 and susceptibility to atherogenesis.Semantic proximity Read ↗

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