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Article

Paraoxonase gene polymorphisms are associated with carotid arterial wall thickness in subjects with familial hypercholesterolemia.

Atherosclerosis - 1 Apr 2000

Leus F R, Wittekoek M E, Prins J, Kastelein J J, Voorbij H A

Abstract excerpt

Human serum paraoxonase (PON) is a high density lipoprotein (HDL) associated enzyme capable of hydrolyzing lipid peroxides in vitro. PON has recently attracted attention as a protective factor against oxidative modification of LDL and may therefore play an important role in the prevention of the atherosclerotic process. Two frequent mutations at the paraoxonase gene locus (PON1) are the leucine (L...

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Source

Identifiers

PMID: 10729387
DOI: 10.1016/s0021-9150(99)00324-x

Genes

PON1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Paraoxonase gene polymorphisms are associated with carotid arterial wall thickness in subjects with familial hypercholesterolemia.PMID 10729387Read ↗

Variation at the paraoxonase gene locus contributes to carotid arterial wall thickness in subjects with familial hypercholesterolemia.Semantic proximity Read ↗

Influence of the human paraoxonase polymorphism (PON1 192) on the carotid-wall thickening in a healthy population.Semantic proximity Read ↗

A paraoxonase gene polymorphism, PON 1 (55), as an independent risk factor for increased carotid intima-media thickness in middle-aged women.Semantic proximity Read ↗

Paraoxonase genotype and carotid intima-media thickness in children with familial hypercholesterolemia.Semantic proximity Read ↗

Genetic associations and serum paraoxonase levels with atherosclerosis in western Iranian patients.Semantic proximity Read ↗

Paraoxonase PON1 polymorphism leu-Met54 is associated with carotid atherosclerosis: results of the Austrian Stroke Prevention Study.Semantic proximity Read ↗

Effect of the human serum paraoxonase 55 and 192 genetic polymorphisms on the protection by high density lipoprotein against low density lipoprotein oxidative modification.Semantic proximity Read ↗

p.Q192R SNP of PON1 seems not to be Associated with Carotid Atherosclerosis Risk Factors in an Asymptomatic and Normolipidemic Brazilian Population Sample.Semantic proximity Read ↗

The Arg allele in position 192 of PON1 is associated with carotid atherosclerosis in subjects with elevated HDLs.Semantic proximity Read ↗

PON2 gene variants are associated with clinical manifestations of cardiovascular disease in familial hypercholesterolemia patients.Semantic proximity Read ↗

Paraoxonase producing PON1 gene M/L55 polymorphism is related to autopsy-verified artery-wall atherosclerosis.Semantic proximity Read ↗

Paraoxonase 1 gene polymorphisms and enzyme activities in coronary artery disease and its relationship to serum lipids and glycemia.Semantic proximity Read ↗

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