Article
Genetic and environmental determinants of the PON-1 phenotype.
European journal of clinical investigation - 1 Mar 2007
Roest M, van Himbergen T M, Barendrecht A B, Peeters P H M, van der Schouw Y T, Voorbij H A M
Abstract excerpt
BACKGROUND: Paraoxonase (PON-1) is a high-density lipoprotein (HDL)-associated enzyme that may protect against cardiovascular disease (CVD), because it hydrolyses oxidized phospholipids of low-density lipoprotein (LDL) and therefore prevents the detrimental effects on the arterial wall. The current report describes the determinants of PON-1 bioavailability and activity. MATERIALS AND METHODS: This is the largest...
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